Quick Summary: A product-by-product breakdown of the Naturium Multi-Peptide collection – one of the best more affordable peptide ranges around – covering the moisturiser, eye cream, advanced serum and rich cream, plus the specific peptides in each.
The Naturium Multi-Peptide collection is probably one of the best more affordable skincare ranges on the market, especially if peptides are something that interest you.
They’re also really great formulations for general skin health with lots of hydrators. Accessible peptides – but how to choose? Here’s a breakdown of each product and the peptides behind it.
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Naturium Multi-Peptide Moisturizer, $38.00
Soft creamy texture with smooth glide and neutral pillowy dry down.
Quick overview: This is not just multi-peptide, but multi-everything. Featuring moisturiser classics like glycerin, dimethicone, jojoba oil, squalane. Plus niacinamide, panthenol, and also ethylated ascorbic acid. This is basically a serum-in-cream.
Cool to know: The encapsulated ethylated ascorbic acid is delivered in a niosomal vesicle coupled with two magnolia extracts for additional antioxidant and anti-inflammatory support. This complex is designed to further increase bioavailability.
Best for: Don’t let the nutrient dense formula fool you – this is light, effortless, and incredibly easy to use. A true multitasker, it sneaks in well rounded skincare technology without a hefty price tag. Perfect for everyday users who want a bit of everything without layering lots of serums.
Note: Dry skin types (or anyone who prefers an emollient texture) may not enjoy as much. This flirts with feeling a bit like a moisturising primer.
The Peptides: Matrixyl 3000 And Syn-Coll
Palmitoyl Tripeptide-5, often known as Syn-Coll, or as a 4-in-1 anti-ageing complex (with sodium hyaluronate, panthenol, dunaliella salina algae). PT-5 is a synthetic signalling peptide targeting collagen production. While dunaliella has a reputation of helping combat signs of glycation.
Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 together are known as Matrixyl 3000. Matrixyl 3000 peptides mimic naturally occurring peptides that are released from the extracellular matrix known as matrikines. The action of these peptides is often described as applying a fragment of a macromolecule already present in the skin that then tricks the skin into thinking damage or a wound has occurred. This triggers a cascade of repair responses resulting in enhanced collagen, fibronectin, and hyaluronic acid production.
Matrixyl 3000 has been around for a long time, but its reputation in skincare keeps developing. More recent supplier information suggests it is indicated in the expression of progerin, which is a marker of senescence known to accumulate with age. Senescence is the accumulation of zombie cells which is a field of interest for ageing.
MP Moisturizer also uses a natural source of peptides coming from Sacha Inchi. This ingredient has been processed in a way to make these naturally occurring peptides more bioavailable.
Naturium Multi-Peptide Eye Cream, $30.00
A more targeted version of Multi-Peptide Moisturizer featuring a paste-like texture that melts to a buttery veil.
Quick overview: This simplifies the face cream by omitting niacinamide and ethylated ascorbic acid (maybe to improve gentleness) but adds an additional feature peptide to round out the formula.
The Peptides: Syn-Eye And Argireline Amplified
Cool to know: MP Eye Cream appears to use the same PT-5 peptide complex (Syn-Eye) as the moisturiser as well as Matrixyl 3000. Both targeting collagen production. But, this has an additional peptide added called Argireline Amplified. The original Argireline has a long standing reputation, similar to that of Matrixyl.
Just this has specifically been touted as a dynamic expression line peptide. The Amplified version has a smaller molecular size thought to penetrate the skin even better leading to quicker and more enhanced results. Argireline Amplified (Acetyl Hexapeptide-8) will be discussed more shortly.
Best for: This is a slightly more dry feeling eye cream that also isn’t overly emollient. Generally, the eye contour shows the first signs of ageing, usually fine lines, so this eye cream could be a good one to integrate if that’s your primary concern and you enjoy textures that blend into the skin without imparting obvious moisture.
Matrixyl peptides and Argireline are probably the two most well known and loved peptides… ever.
Naturitum Multi-Peptide Advanced Serum, $47.00
This is probably my favourite product that Naturium makes as it has a milky emulsion texture but still feels light to allow for easy product layering. It makes my skin feel incredibly smooth, plump, and comforted.
Quick overview: The Multi-Peptide Advanced Serum is an evolution of the original multi-peptide products, with maybe a more modern scope of ingredients and also an enhanced focus on antioxidant protection by way of ferulic acid.
Cool to know: The ferulic acid Naturium uses is also encapsulated, this is probably what leads to the smoky metallic scent this serum has. The (presumed) supplier claims they’re able to increase the delivery of ferulic acid into the epidermis by 472% thus allowing for enhanced activity, better antioxidant protection against UV rays, and also more sustained activity.
Best for: There’s not much overlap between the serum and moisturiser so you could use both together to capture a breadth of different ingredients – or one in the morning and one at night. Easy to slot in, and a great way to integrate advanced peptides for a good value. This serum imparts a subtle radiance to the skin and leans lighter in texture, best used as a layering product.
The Peptides: Argireline Amplified And Copper Peptides
The MP serum appears to focus on Argireline Amplified as the key peptide, which is also featured in the eye cream but not moisturiser. As alluded to in the eye cream section, Argireline Amplified is thought to act on dynamic expression lines by targeting the assembly of the SNARE complex, specifically targeting SNAP-25. Blocking this interaction supposedly leads to a reduction in muscle contraction. Quite lofty claims, haha.
Beyond Argireline Amplified, they’ve also added encapsulated copper peptides. I believe the form of encapsulated copper peptides they’re using is known as X50 Antiaging Solution.
Essentially thought to increase the production of collagen and elastin but in a way where the ingredients are more protected and delivered into the skin more effectively due to the encapsulation. It’s supposed to have a cell targeting capability known as drone technology that also allows for more sustained activity in the skin.
I’ve always wondered if this version of a copper peptide replaces what we typically see, in like the blue serums. From what I’ve been able to find, the blue serums have a better reputation for actual skin regeneration and healing.
Naturium Multi-Peptide Rich Cream, $47.00
The newest product in the MP lineup. I’m pretty sure this is a water-in-oil emulsion which is different to most moisturisers that are oil-in-water. A water-in-oil emulsion tends to feel richer. I would compare this texturally, and the overall experience of using it, to the Augustinus Bader The Rich Cream.
Quick overview: An entirely different moisturising sensation from the original Multi-Peptide Moisturizer. This feels more occlusive and has an oil-forward skin feel. With some innovative call outs including a gold-stabilised peptide.
Cool to know: Naturium Rich Cream is texturally interesting. When you first apply, the immediate sensation is a rich, creamy, fairly thick texture.
But then it’s like it bursts on the skin, and you get this quick hit of watery hydration. Almost immediately after the burst, the emollient and oilier texture returns as you continue to rub it in.
Honestly, there are moments where it feels like it’s repelling its own application, and this is much more pronounced than I’ve noticed before in other creams. It requires a little bit of extra time to properly spread and sink in.
But once it does, it’s like it sticks to the skin, as a second skin. The first few times I used this, it felt kind of odd. I’ve since grown to enjoy the textural experience.
Best for: Anyone that prefers heavier cream textures. Probably leans towards dry skin compatibility, but I’m fairly congestion prone, and happily use it at night with no issue. It’s a bit too shiny for me in the day.
The Peptides: GHK-Cu And Bellativa Golden Matrix
Naturium use a different peptide complex entirely in this that I’m pretty sure is called Bellativa Golden Matrix. Basically, conjugating what was the original Matrixyl peptide sequence with a centella extract and gold.
I couldn’t find too many claims about this but essentially this forms a more stable delivery system to protect the peptide and enhance its collagen boosting properties.
They’ve also added the classic copper peptide Copper Tripeptide-1 also known as GHK-cu. I’m unclear on the actual best amount to use in terms of dose, but often peptides function from very low amounts, even something like 0.1%.
As I mentioned briefly earlier, copper peptides are thought to have a large scope of rejuvenating effect where they can help with evening skin tone, reduce lines and wrinkles, and help with firmness and elasticity.
The running theme with all Naturium products surrounds stability and using what is essentially the best-in-class methods for protecting these molecules and ensuring they remain active as possible. The other benefit of encapsulation/conjugation is that layering with other things is even more of a no brainer.
A Note On Deciphering Ingredients And Understanding Peptides
Deciphering an INCI list is tough without brand-disclosed trade names. I’ve done my best to connect the dots, but since so many ingredients have multiple suppliers, there’s room for error.
As I’m not a chemist, I’ve manually searched each individual ingredient and its potential combinations.
Most claims I reference come from supplier data, not Naturium, and supplier-backed research doesn’t always reflect real-world results.
Naturium now shares its own product testing (check their site). Peptides, in particular, rely heavily on in vitro data with bold claims, but real-world results are likely going to be more subtle.
I believe in the use of peptides as a booster to retinoids and sunscreen. Results take time, often many months.
Final Thoughts
The Naturium Multi-Peptide range stands out because it makes well-formulated, stability-focused peptides affordable.
The moisturiser is the easy all-rounder, the advanced serum is the standout, the eye cream and rich cream target more specific textures and concerns – and there’s not much overlap, so they layer well together.
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